BI Xiuli, a professor at School of Life Science, Liaoning University, received B.S. from Hebei Medical University in 2000, obtained her Ph.D on Pharmacology in 2005 at Shenyang Pharmaceutical University, China, completed the postdoctoral research during 2005-2007 in University of Alabama at Birmingham in USA, and worked as Research associate and Instructor in University of Illinois at Chicago in USA during 2007-2010.
Our lab research focuses on the carcinogenesis and chemoprevention of colorectal cancer. Particular the role of tumor microenvironment in the formation and development of colorectal cancer, and the role of epigenetic regulation in Wnt signaling pathway in colorectal prevention using natural factors intervention is the current research focus.
The represent research achievements are as followed:
1. Bi X, Shi Q, Zhang H, Bao Y, Hu D, Pohl N, Fang W, Dong H, Xia X, Fan D, Yang W. c-Jun NH2-teminal kinase 1 interacts with vitamin D receptor and affects vitamin D-mediated inhibition of cancer cell proliferation. J Steroid Biochem Mol Biol. 2016 Oct;163:164-72. IF: 3.89
2. Bi X, Xia X, Fan D, Mu T, Zhang Q, Iozzo RV, Yang W. Oncogenic activin C interacts with decorin in colorectal cancer in vivo and in vitro. Mol Carcinog. 2016 Nov;55(11):1786-1795.. IF: 4.8
3. Bi X, Pohl N, Dong H, Yang W. Selenium and sulindac are synergistic to inhibit intestinal tumorigenesis in Apc/p21 mice. J Hematol & Oncol. 2013, 17: 6-8. IF: 4.5
4. Wang LD*, Bi X*, Song X, Pohl NM, Cheng Y, Zhou Y, Shears S, Ansong E, Xing M, Wang S, Xu XC, Huang P, Xu L, Wang L, Fan Z, Zhao X, Dong H, Meltzer SJ, Ding I, Yang W. A sequence variant in the phospholipase C epsilon C2 domain is associated with esophageal carcinoma and esophagitis. Mol Carcinog. 2013 Feb 6. doi: 10.1002/mc.22016. [Epub ahead of print] [* Co-first author] IF: 4.3
5. Bi X, Pohl NM, Qian Z, Yang GR, Gou Y, Guzman G, Kajdacsy-Balla A, Iozzo RV, Yang W. Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice.Carcinogenesis. 2012 33 (2) 326-30 IF: 5.44
6. Bi X, Pohl NM, Yin Z, Yang W. Loss of JNK2 Increases Intestinal Tumor Susceptibility in Apc1638+/- Mice with Dietary Modulation. Carcinogenesis, 2011 32(4) 584-588 IF: 5.44