Prof. YE Chen under takes multiple key positions in Liaoning University. The positions are pharmaceutical researcher; director of the department of pharmacy and director of the Laboratory of Pharmaceutical Chemistry of School of Pharmacy; member of the Academic Degrees Committee; and director of drug design and R & D laboratory.
He is also a special-term Professor of Liaoning He University and the deputy director of Key Laboratory of New Drug R & D of Liaoning Province.
YE Chen, majored in Pharmacy, received B.Sc. degree in Shenyang Pharmaceutical University. After graduation in 1988, he joined Institute of Liaoning Pharmaceutical Industry Research. And moved to Liaoning University in 2005. His special expertise are research, development and management of brand new drug; and the development and registration of enterprise projects (new drug category). In addition, he is also responsible for organization and coordination of the project industrialization.
In the same period, he also worked as a deputy general manager and division director of pharmaceutical health care products of Shenyang Eurasia Group (1995 - 2000). He also work as a deputy general manager in Shenyang Syndy Pharmaceutical Co. Ltd. (2001 - 2005).
He leads a productive research group with talents from multi-discipline backgrounds, including pharmaceutical chemistry, pharmacology, pharmaceutics and other disciplines, as well as his own students. His research focuses on anti-tumor and anti-resistant bacteria innovative drugs which targets at receptor, enzyme and nucleic acid. He had participated in several major national innovation of drug research. Great progress was made by design and synthesis of a series of compounds with high activity in the study of drugs such as tyrosine kinase and telomerase inhibitors. At the same time, he has also carried out me-too drug development and evaluation of drug efficacy and quality consistency. A number of invention patents were applied. The honorary title "Experts of Science and Technology of Liaoning Province" was awarded to him by the Office of Science and Technology of Liaoning Province.Apart from academic appointments, he also acts as review experts of the Ministry of Science and Technology Torch Program,Ministry of Education graduate thesis,Science and Technology of Liaoning province,Cleaner production audit of Liaoning Provincial Environmental Protection Office,Science and technology project of Shenyang,Science and Technology project of Huludao City, Liaoning Province,Science and Technology Innovation Committee of Qingdao University,"Chinese Medical Guide" magazine peer review, andNational Licensed Pharmacist.
He had won the third prize of Progress in Science and Technology of Liaoning Provincial government, the second prize of Progress in Medical Science and Technology of Liaoning province and Achievements of Provincial and Municipal Scientific Research for three times. Sixteen new drug certificates and production approvals and one national health food certificate were granted to his researches. At the same time, he had won the majored projects of "Major New Drugs Innovation and Development" of China's 11th Five-Year Plan and 12th Five-Year Plan" and served as deputy head of the task.
He has won the funds from National Torch Programs twice, National Science and Technology Innovation Funds twice, Chinese National Natural Science Foundations twice, three provincial projects, a number of municipal projects, and more than 30 industrial projects. He is granted 5 patents, 14 patent applications and one PCT international patent application. He is the first inventor of 10 inventions. He hold dozens of publications in the field of pharmaceutical science. In Liaoning University, he offers many graduate and undergraduate courses, including Drug Design and Development, Pharmaceutical Management and GMP, Introduction to Pharmacy and many other courses.
B.Sc Shenyang Pharmaceutical University 1988
Professor, School of Pharmaceutical Science, Liaoning University(2005– ).
Deputy general manager and division director, Pharmaceutical health care products of Shenyang Eurasia Group (1995 - 2000).
Deputy general manager , Shenyang Syndy Pharmaceutical Co. Ltd. (2001 - 2005).
Senior pharmaceutical scientist, Liaoning Research Institute for Medicine(1988–2005).
1．New technologies in pharmaceutical dosage, including micro-particulate and nano-particulate drug delivery systems; thixotropic fluid delivery systems; macromolecular drug delivery systems; polymeric micelles and polymeric substances; ophthalmic, vaginal and rectal administration systems; and modified Release formulations.
2．In-vivo analysis and development of new drugs (including preparation process, test method and specifications, drug product stability, bioavailability and pharmacokinetic studies).
3．Innovative design, synthesis, in vitro screening and toxicity evaluation of anti-cancer drugs, anti-infection and anti-diabetic drugs.
1． “A preclinical study of the first type of new drug for drug resistance-cyclamiphene maleate”. Won National "Twelfth Five-Year" Plan "Major new drug creation" major science and technology projects in 2011, 3,436,300yuan, and served as the host in Liaoning University sub-project.
2．“Effects of selenium Selk on phagocytosis and migration of microglia and monocytes and its relationship with Alzheimer's disease”. Won the "National Natural Science Fund Project" in 2013, project funding was 780,000.
3．“The study of A New Chiral Reversed Bonded Phase Filler RP11 for the pharmaceutical industry manufacturing” in 2016. Key Laboratory of the Department of Education Project
4．"The Preclinical study of the first type of new anti-tumor drugs Cyclotinib (CB1107) with a dual inhibitory effect on both Bcr-Abl and c-Kit protein tyrosine kinases" in 2016. Social development project in Shenyang City, 500,000 yuan project.
5．“ Study on the mechanism of inhibition of microglia activation by nine bis - benzylisoquinoline alkaloids based on the ROS / NF-κB pathway”in 2014. Natural Science Foundation of Science and Technology Department in Liaoning Province.
6．“ The research of process optimization and industrialization of amplification of the first type of new anti-MRSA super-resistant bacteria drugs HMNP” in 2012. 400,000yuan.
7．“Research Center of Natural Products Pharmaceutical Engineering Technology in Liaoning Provincial ” in 2012. The Center Project of Provincial Science and Technology Department Project.
8．“A preclinical study of the first type of new anti-tumor drugs Hydroxymorph”. Social Development project in Shenyang City in 2011. 200,000yuan .
9．“Study on candidate drug of the first type of new anti-tumor drugs Garcinia Glycoside ”. Social Development project in Shenyang City in 2010. 400,000yuan.
10．.“Study on Anti - tumor mechanism and target of action of Hydroxymorph”. “Pre-financing funds of Liaoning University” in 2010, project funding was 9000; Lead.
11．“ The research of process optimization and industrialization of amplification of the first type of new anti-tumor drugs Garcinia Glycoside” in 2010. Social Development project in Shenyang City, 400,000yuan.
12．“Study on candidate drug of the first type of new anti-tumor drugs Garcinia Glycoside ”. National "Twelfth Five-Year" Plan "Major new drug creation" major science and technology projects in 2009, 1,490,000yuan. Deputy head of the task group and the host in Liaoning University sub-project.
13．.“Innovative R & D testing technical service support of the first type of new anti-tumor drugs” Instruments and equipment sharing special project in Shenyang, in 2008. 200,000 yuan.
14．“ Preparation of high purity paclitaxel from branches and leaves of Taxus baccata by using new high - resolution packing” Torch Plan of Ministry of Science and Technology and Innovation fund project in 2004. 1,000,000yuan.
15．“The study of A New Chiral Reversed Bonded Phase Filler RP11 for the pharmaceutical industry manufacturing” in 2007. The project of Provincial Education department.
16． “The new technology research of chlorpheniramine male”. Torch Plan of Ministry of Science and Technology and Innovation fund project in 2001. 600,000yuan.
1．Yang Wang, Shuang Han, Di Cao, Ju Liu, Yunpeng Zhou, Lifeng Xu, Ye Chen*.Preparation of High Purity Capsaicin Monomer by Reverse Phase C18 Column Chromatograph[J].Food Science.2013,34(24):65-68.
2．Ye Chen, Hong Lu, Xiaolin Lin, Rui Wang, Ju Liu, Yunpeng Zhou, Yang Wang.Pharmacokinetic and pharmacodynamic properties of cycpyrimidiniping maleate in vitro[J].Chinese Journal of New Drugs,2013(24):2924-2928.
3．Ju Liu, Meirong Zhang, Yang Wang, Yunpeng Zhou, Ye Chen*.Research Progress of Multi-targeted Tyrosine Kinase Inhibitor-Ponatinib[J] .Journal of Liaoning University(Natural Sciences Edition).Journal of Liaoning University(Natural Sciences Edition),2014,41(4):347-355.
4．Ye Chen, Rui Wang, Hong Lu, Jingjing Deng, Jing Liu,Yang Wang, Ju Liu. Evaluation of Clinical Testing Method for Detection of MethiciHin-resistant Staphylococcus[J], Journal of Liaoning University(Natural Sciences Edition),2013,40(3).
5．Lili Yin, Jing Liu, Cuiying Ren, Yinghui Chen, Shan Jiang, Yunpeng Zhou, Yang Wang, Ye Chen*.Effects of Hydroxyl Morpholine Resistance on K562 Cells of Chronic Myelocytic Leukemia[J].Chinese Pharmaceutical Journal,2016(5):368-372.
6．Ye Chen, Longjie Zhang, Yujia Kang, Guanghui Zou, Di Li, Yunpeng Zhou, Yang Wang.Pharmacokinetics and Distibution of Hydroxyl Morpholine in Rats[J] , Journal of Liaoning University(Natural Sciences Edition),2016(2).
7．Yang Wang, Qijing Zhang, Ju Liu, Shuang Han, Qiushi Zhang, Ye Chen*, Yunpeng Zhou.Synthesis and antitumor activities of gareinia glycosides[J].Chinese Journal of New Drugs, 2013(23):2739-2744.
8．Shengjun Ji, Jing Liu, Jingjing Deng, Wenjun Li, Ying Jin, Shuang Han, Ju Liu, Yunpeng Zhou, Lifeng Xu,Ye Chen*.Study on acute toxicity，genetoxicity and reproductive toxicity（the second stage of the rat）of garcinia glycosides[J].Chinese Journal of New Drugs and Clinical Remendies, 2014(10):729-734.
9．Ye Chen, Shibo Song, Yuanpeng Fu, Longjie Zhang, Yinghui Chen, Lifeng Xu.Development and Special Safety of TJXG Nanoemulsion[J] , Journal of Liaoning University(Natural Sciences Edition), 2015，42(1), 58-64.
10．Yuanpeng Fu, Rui Wang, Tongmin Li, Lin Jia, Xiaolin Lin, Ye Chen*.Pharmacokinetics and tissue distribution of TJXG nano emulsion in rats[J].China Medical Herald, 2013, 10(11):19-21.
11．Cuiying Ren, Yinghui Chen, Longjie Zhang, Wenjun Li, Di Li, Yunpeng Zhou, Wang Yang, Ye Chen*.Preparation of Garcinia Glycoside Bilayer Tablets and Its in Vitro Release[J].Chinese Pharmaceutical Journal,2016(9).
12．Ye Chen, Lin Jia, Yumei Bao, Wenjun Li, Yuanpeng Fu, Yang Wang.The Preparation and the Determination of Content and Entrapment Efficiency by HPLC of the Sustained Release Microspheres of Tinidazole[J] , Journal of Liaoning University(Natural Sciences Edition). 2013, 40(4).
13．Yuanpeng Fu, Penghong Guo, Wenjun Li, Ye Chen*.Dynamics study on the intestinal absorption of AB0315 in rats[J].China Medical Herald, 2012, 9(36):22-24.
14．Jingjing Deng, Sengjun Ji, Ye Chen*, Xiaolin Lin, Rui Wang, Lifeng Xu.Evaluation of the inhibitory effect of garcinia glycosides on growth of human tumor cells by hollow fiber assay[J].Journal of Pharmaceutical,2014(4):266-269.
15．Ye Chen, Yunpeng Zhou, Lifeng Xu, Rui Wang, Ju Liu. Simultaneous Determination of (+)-Catechin and(-)- Epicatechin in Daiyuan Capsule by HPLC[J] , Journal of Liaoning University(Natural Sciences Edition),2008, 35(3):267-270.
16．Ye Chen, Yunpeng Zhou, Jingjing Deng, Dehong Tan, Lifeng Xu.Smiultaneous Determination of Ciprofloxacin hydrochloride and Dexamethasone Acetate in Compound Ciprofloxacin Hydrochloride Ear Drops by HPLC[J], Journal of Liaoning University(Natural Sciences Edition), 2006, 33(4):327-330.
17．Ye Chen, Yang Wang, Zhongchen Liu, Wenjun Li, Jingjing Deng, LifengXu.Preparation and in vitro release of Garcinia glycosides sustained-release tablets[J]. Journal of Pharmaceutical 2012, 30(5):369-371.
18．Ye Chen, Ying Zheng, Lifeng Xu. Everolimus Treated Anti-RCC Current Research Progress[J]. Journal of Liaoning University(Natural Sciences Edition), 2011, 38(1):60-66.
19．Ye Chen, Yunpeng Zhou, Lifeng Xu. Preparation and Efficacy Evaluation Research for Zhonghua Biology Ginseng[J]. Journal of Liaoning University(Natural Sciences Edition), 2007, 34(4):354-357.
1．Pharmaceutical composition preparations containing hydroxymorpholine or hydroxymorpholine pharmaceutical complexes( patent authorization),China, CN20101075134
2．Antitumor drugs chroman (thiopyran) amide compounds and its pharmaceutically acceptable salt and its preparation and application( patent authorization), China, CN2014102405657
3．Substituted indanamide compounds and its pharmaceutically acceptable salt and its preparation and application, China, CN2014104669522
4．A pharmaceutical preparation of rapid release of Cyclotinib Citrate and its preparation, China,CN2013101726711
Antitumor drugs Tetrahydronaphthalene amide compounds and its pharmaceutically acceptable salt and its preparation and application, China, CN201010010170X
5．Substituted tetrahydronaphthalene amides and its pharmaceutically acceptable salt and its preparation and application( patent authorization), China, CN201410466940X
6．Methylnaphtho [1,2-b] furanamide-based compounds and its pharmaceutically acceptable salt and its preparation and application( patent authorization), China, CN2014105968771
7．A high drug loading tablet comprising a tetrahydronaphthalene amide compound or its pharmaceutically acceptable salt( patent authorization), China, CN201301748640
8．Antitumor drugs Hydroxymorph and its derivatives and its preparation and application, ( patent authorization), China, CN201010010170X
Institute of Pharmacy, Liaoning University,
No.66 Chongshan Middle Road, Huanggu District, Shenyang,Liaoning, China 110036