Associate professor LIU Bingmi obtained her B. Eng. degree from the college of Chemistry and Chemical Engineering at Chongqing University, China in 1998. Then she worked as an assistant engineer for four years in CSPC Hebei Zhongrun Pharmaceutical Co., Ltd., China. After that, she received her M.Sc. and Ph.D. degrees, both in Medicinal Chemistry from Shenyang Pharmaceutical University, China in 2005 and 2013, respectively. She is currently engaged in teaching and research in the School of Pharmaceutical Sciences at Liaoning University.
Her research interests are in studying the relationships between the chemical structures, modification and anti-tumor activities of natural products, and discuss the molecular mechanism, and their sonodynamic anticancer activity. So far, she published 14 articles, and the majority of the articles were included in SCI journals. In addition, she attained the authorized country invention patent 1 item, and 2 provincial-level natural science academic achievement awards.
B. Eng., Chongqing University, China, 1998
M.Sc., Shenyang Pharmaceutical University, China, 2005
Ph.D., Shenyang Pharmaceutical University, China, 2013
Associate Professor, School of Pharmaceutical Science, Liaoning University (2005– )
Assistant engineer, CSPC Hebei Zhongrun Pharmaceutical Co., Ltd. (1998–2002)
1. The chemical structures, modification and antitumor activities of natural products
2. Sonodynamic anticancer activities of natural products and their analogues
3. Binding of small-molecule ligands to proteins
1．Bing-Mi Liu*, Jun Zhang, Ai-Jun Hao, Liang Xu, Dan Wang, Hui Ji, Shi-Jie Sun, Bo-Qi Chen, Bin Liu*. The increased binding affinity of curcumin with human serum albumin in the presence of rutin and baicalin: a potential for drug delivery system. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 155 (2016) 88–94.
2．Bing-Mi Liu, Jun Zhang, Xin Wang*, Li-Ping Zhang, Yang Liu, Hua-Ying Niu , Bin Liu*. Synthesis, DNA interaction and antimicrobial activities of three rimantadine analogues. Journal of Luminescence, 159 (2015) 128–133.
3．Bing-Mi Liu*, Chong-Liang Bai, JunZhang, YangLiu, Bo-YangDong, Yi-TongZhang, Bin Liu*. In vitro study on the interaction of 4,4-dimethylcurcumin with calfthymus DNA. Journal of Luminescence, 166 (2015) 48–53.
4．Bing-Mi Liu*, Jun Zhang, Chong-Liang Bai, Xin Wang, Xin-Zhi Qiu, Xiao-Li Wang, Hui Ji, Bin Liu*. Spectroscopic study on flavonoid-drug interactions: competitive binding for human serum albumin between three flavonoid compounds and ticagrelor, a new antiplatelet drug. Journal of Luminescence, 168 (2015) 69–76.
5．Bing-Mi Liu, Jun Zhang, Yang Liu, Li-Ping Zhang, Ping Ma, Xin Wang * and Bin Liu*. Multi-spectroscopic methods investigation on the interaction of tenoxicam with DNA. Luminescence, 30 (2015) 1313–1317.
6．LIU Bing-mi*, ZHANG Mei-hui, TAO Shu-juan, XIA Ming-yu, DONG Jin-hua*. Synthesis and antiproliferative effect of Mannich bases of demethoxycurcumin derivatives. Chinese Journal of Medicinal Chemistry, 24 (2014) 271–278.
7．Bing-Mi Liu, Ping Ma, Xin Wang, Yu-Mei Kong, Li-Ping Zhang, Bin Liu*. Synthesis of Three Rimantadine Schiff Bases and Their Biological Effects on Serum Albumin. Iranian Journal of Pharmaceutical Research, 13 (2014) 1183–1190.
8．Bing-Mi Liu, Ping Ma, Xin Wang, Yu-Mei Kong, Li-Ping Zhang and Bin Liu*. Spectroscopic Investigation on Protein Lesion by Tenoxicam under Ultrasound and Visible-Light Irradiation. Latin American Journal of Pharmacy, 33 (2014) 1492-1496.
9．Liu BM, Xia MY, Ji XL, Xu LY, Dong JH*. Synthesis and antiproliferative effect of novel curcumin analogues. Chemical and Pharmaceutical Bulletin, 61 (2013) 757–763.
10．Liu B*, Wang DJ, Liu BM, Wang L, He LL, Wang J, Xu SK. The influence of ultrasound on the fluoroquinolones antibacterial activity. Ultrasonics Sonochemistry, 18 (2011) 1052–1056.
11．Liu B, Wang DJ, Wang X, Liu BM, Kong YM, Wang D, Xu SK*. Spectroscopic investigation on protein damage by ciprofloxacin under ultrasonic irradiation. Spectrochimica Acta Part A, 78 (2011) 712–717.
12．Bin Liu, Jun Wang, Xin Wang, Bingmi Liu, Lingling He, Shukun Xu*. Synthesis and characterization of polymer eight-coordinate (enH2)[YIII(pdta) (H2O)]2·10H2O as well as the interaction of [YIII(pdta)(H2O)]22- with BSA. Spectrochim Acta A, 77 (2010) 1115–1121.
13．Liu B*, Wang J, Wang X, Liu BM, Kong YM, Wang D, Xu SK*. Spectrometric studies on the sonodynamic damage of protein in the presence of levofloxacin. Journal of Fluorescence, 20 (2010):985–992.
14．Ling-Ling He, Xin Wang*, Xiao-Xia Wu, Yong-Xia Wang, Yu-Mei Kong, Xin Wang, Bing-Mi Liu, Bin Liu. Protein damage and reactive oxygen species generation induced by the synergistic effects of ultrasound and methylene blue. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 134 (2015) 361–366.
1. Curcumin analogues, their medicinal salts and preparations and applications License number: ZL201210502684.6.
2. Four hydrogen curcumin analogues and their preparations and uses. Notice number: CN104098457A
School of Pharmaceutical Sciences, Liaoning University,
No.66 Chongshan Mid-Road, Huanggu District, Shenyang, Liaoning, China 110036