ZHANG Li

 Position: Lecturer

Email: lizhang@lnu.edu.cn

Tel: +86(0)2462202232

 Contact details:

College of Life Sciences, Liaoning University

Huanggu - 66 - Chongshanzhong Road

110036 Shenyang, China

 Research interests:

Bioinformatics

Research and Development of Computer-aided Drug Design Method Based on Artificial Intelligence

 Teaching:

Bioinformatics

 Career path:

Bachelor: College of Life Sciences, Liaoning University, Biotechnology

Master: College of Life Sciences, Liaoning University, Biochemistry and Molecular Biology

Doctorate: College of Life Sciences, Liaoning University, Biostatistics & Health Statistics

Researcher: College of Life Sciences, Liaoning University, Shenyang, China

 Publications:

1.Zimo Yin, Haixin Ai, Li Zhang, Guofei Ren, Yuming Wang, Qi Zhao, and Hongsheng Liu, Predicting the cytotoxicity of chemicals using ensemble learning methods and molecular fingerprints. Journal of Applied Toxicology, 2019. 0(0).

2.Haixin Ai, Xuewei Wu, Li Zhang, Mengyuan Qi, Ying Zhao, Qi Zhao, Jian Zhao, and Hongsheng Liu, QSAR modelling study of the bioconcentration factor and toxicity of organic compounds to aquatic organisms using machine learning and ensemble methods. Ecotoxicology and Environmental Safety, 2019. 179: p. 71-78.

3.Li Zhang, Hui Zhang, Haixin Ai, Huan Hu, Shimeng Li, Jian Zhao, and Hongsheng Liu, Applications of Machine Learning Methods in Drug Toxicity Prediction. Current topics in medicinal chemistry, 2018. 18(12): p. 987-997.

4.Liang Xu, Yanxi Hu, Yancheng Li, Li Zhang, Haixin Ai, Yufeng Liu, and Hongsheng Liu, In vitro DNA binding studies of lenalidomide using spectroscopic in combination with molecular docking techniques. Journal of Molecular Structure, 2018. 1154: p. 9-18.

5.Huan Hu, Li Zhang, Haixin Ai, Hui Zhang, Yetian Fan, Qi Zhao, and Hongsheng Liu, HLPI-Ensemble: Prediction of human lncRNA-protein interactions based on ensemble strategy. RNA biology, 2018. 15(6): p. 797-806.

6.Haixin Ai, Li Zhang, Jikuan Zhang, Tong Cui, K. Chang Alan, and Hongsheng Liu, Discrimination of Thermophilic and Mesophilic Proteins Using Support Vector Machine and Decision Tree. Current Proteomics, 2018. 15(5): p. 374-383.

7.Haixin Ai, Xuewei Wu, Mengyuan Qi, Li Zhang, Huan Hu, Qi Zhao, Jian Zhao, and Hongsheng Liu, Study on the Mechanisms of Active Compounds in Traditional Chinese Medicine for the Treatment of Influenza Virus by Virtual Screening. Interdisciplinary Sciences: Computational Life Sciences, 2018. 10(2): p. 320-328.

8.Haixin Ai, Wen Chen, Li Zhang, Liangchao Huang, Zimo Yin, Huan Hu, Qi Zhao, Jian Zhao, and Hongsheng Liu, Predicting drug-induced liver injury using ensemble learning methods and molecular fingerprints. Toxicological Sciences, 2018. 165(1): p. 100-107.

9.Junfeng Zhu, Ying Xu, Chunyu Zhu, Jian Zhao, Xinrui Meng, Siyao Chen, Tianqi Wang, Xue Li, Li Zhang, Changlong Lu, Hongsheng Liu, and Sun Xun, IL-33 induces both regulatory B cells and regulatory T cells in dextran sulfate sodium-induced colitis. International immunopharmacology, 2017. 46: p. 38-47.

10.Li Zhang, Haixin Ai, Shimeng Li, Mengyuan Qi, Jian Zhao, Qi Zhao, and Hongsheng Liu, Virtual screening approach to identifying influenza virus neuraminidase inhibitors using molecular docking combined with machine-learning-based scoring function. Oncotarget, 2017. 8(47): p. 83142-83154.

11.Li Zhang, Haixin Ai, Wen Chen, Zimo Yin, Huan Hu, Junfeng Zhu, Jian Zhao, Qi Zhao, and Hongsheng Liu, CarcinoPred-EL: Novel models for predicting the carcinogenicity of chemicals using molecular fingerprints and ensemble learning methods. Scientific Reports, 2017. 7(1): p. 2118.

12.Liang Xu, Yanxi Hu, Yancheng Li, Li Zhang, Haixin Ai, Hongsheng Liu, Yufeng Liu, and Yuli Sang, Study on the interaction of tussilagone with human serum albumin (HSA) by spectroscopic and molecular docking techniques. Journal of Molecular Structure, 2017. 1149: p. 645-654.

13.Liang Xu, Yanxi Hu, Yancheng Li, Yufeng Liu, Li Zhang, Haixin Ai, and Hongsheng Liu, Study on the interaction of paeoniflorin with human serum albumin (HSA) by spectroscopic and molecular docking techniques. Chemistry Central Journal, 2017. 11(1): p. 116.

14.Liang Xu, Yanxi Hu, Jin Li, Yufeng Liu, Li Zhang, Haixin Ai, and Hongsheng Liu, Probing the binding reaction of cytarabine to human serum albumin using multispectroscopic techniques with the aid of molecular docking. Journal of Photochemistry and Photobiology B: Biology, 2017. 173: p. 187-195.

15.Hongsheng Liu, Guofei Ren, Huan Hu, Li Zhang, Haixin Ai, Wen Zhang, and Qi Zhao, LPI-NRLMF: LncRNA-protein Interaction Prediction by Neighborhood Regularized Logistic Matrix Factorization. Oncotarget, 2017. 8(61): p. 103975-103984.

16.Huan Hu, Chunyu Zhu, Haixin Ai, Li Zhang, Jian Zhao, Qi Zhao, and Hongsheng Liu, LPI-ETSLP: lncRNA–protein interaction prediction using eigenvalue transformation-based semi-supervised link prediction. Molecular BioSystems, 2017. 13(9): p. 1781-1787.

17.Haixin Ai, Runlin Wu, Li Zhang, Xuewei Wu, Junchao Ma, Huan Hu, Liangchao Huang, Wen Chen, Jian Zhao, and Hongsheng Liu, pSuc-PseRat: Predicting Lysine Succinylation in Proteins by Exploiting the Ratios of Sequence Coupling and Properties. Journal of Computational Biology, 2017. 24(10): p. 1050-1059.

18.Haixin Ai, Yuchen Che, Li Wang, Li Zhang, Ying Gu, Yanni Tan, Alan K Chang, and Hongsheng Liu, Paenibacillus liaoningensis sp. nov., isolated from soil. International journal of systematic and evolutionary microbiology, 2016. 66(8): p. 3150-3156.  

19.Shiwei Wang, Xi Liu, Hongsheng Liu, Li Zhang, Yuan Guo, Shan Yu, Daniel J Wozniak, and Luyan Z Ma, The exopolysaccharide Psl–eDNA interaction enables the formation of a biofilm skeleton in Pseudomonas aeruginosa. Environmental microbiology reports, 2015. 7(2): p. 330-340.

20.Haixin Ai, Fangliang Zheng, Fangbo Deng, Chunyu Zhu, Ying Gu, Li Zhang, Xuejiao Li, Alan K Chang, Jian Zhao, Junfeng Zhu, and Liu Hongsheng, Structure-based virtual screening for potential inhibitors of influenza A virus RNA polymerase PA subunit. International Journal of Peptide Research and Therapeutics, 2015. 21(1): p. 149-156.  

21.Wenjing Zhang, Junyan Tao, Xiaoping Yang, Zhuliang Yang, Li Zhang, Hongsheng Liu, Kailang Wu, and Jianguo Wu, Antiviral effects of two Ganoderma lucidum triterpenoids against enterovirus 71 infection. Biochemical and biophysical research communications, 2014. 449(3): p. 307-312.  

22.Jieliang Ma, Li Zhang, Aaron R Tipton, Jiaping Wu, Angela F Messmer-Blust, Melissa J Philbrick, Yajuan Qi, Songtao Liu, Hongsheng Liu, Jian Li, and Shaodong Guo, Structural and functional analysis of the related transcriptional enhancer factor-1 and NF-κB interaction. American Journal of Physiology-Heart and Circulatory Physiology, 2014. 306(2): p. H233-H242.  

23.Haixin Ai, Li Zhang, Alan K Chang, Hongyun Wei, Yuchen Che, and Hongsheng Liu, Virtual screening of potential inhibitors from TCM for the CPSF30 binding site on the NS1A protein of influenza A virus. Journal of molecular modeling, 2014. 20(3): p. 2142.  

24.Fangliang Zheng, Nan Liu, Yuchen Che, Li Zhang, Lijie Shao, Junfeng Zhu, Jian Zhao, Haixin Ai, Alan K Chang, and Hongsheng Liu, Cloning, expression and characterization of squalene synthase from Inonotus obliquus. Genes & Genomics, 2013. 35(5): p. 631-639.