LIU BingMi, female, was born in May 1974, Han nationality, member of China Democratic League, associate professor, Forensic toxicologist at the Judicial Appraisal Center of Liaoning University. She was graduated from College of Chemistry and Chemical Engineering, Chongqing University in 1998 and received a bachelor’s degree. Then she worked as an assistant engineer for four years in CSPC Hebei Zhongrun Pharmaceutical Co., Ltd., China. In 2002, she was admitted into Shenyang Pharmaceutical University for the study of drug development and graduated in 2005 with a M.Sc. degree in Medicinal Chemistry, and then she joined Department of Pharmaceutical Engineering of Liaoning University as an Assistant Lecturer. During this period, she finished her doctoral course from College of Pharmaceutical Engineering of Shenyang Pharmaceutical University and obtained her Ph.D. degree in Medicinal Chemistry in 2013. After that, she became an associate professor at Liaoning University in 2015. Now, she is currently engaged in teaching and research in the School of Pharmaceutical Sciences at Liaoning University. Her research interests are in studying the relationships between the chemical structures, modification and antitumor activities of natural products, and discusses the molecular mechanism, and their sonodynamic anticancer activity. So far, she published 11 academic papers as the first author and corresponding author and won Liaoning Natural Science Academic Achievement Award and Shenyang Natural Science Academic Achievement Award many times. In addition, she presided and participated in multiple provincial and municipal projects, and two patents have been authorized.
Academic backgroud:
B. Eng., Chongqing University, China, 1998
M.Sc., Shenyang Pharmaceutical University, China, 2005
Ph.D., Shenyang Pharmaceutical University, China, 2013
Career highlights:
Associate Professor, School of Pharmaceutical Science, Liaoning University (2005– )
Assistant engineer, CSPC Hebei Zhongrun Pharmaceutical Co., Ltd. (1998–2002)
Research highlights:
1. The chemical structures, modification and antitumor activities of natural products
2. Sonodynamic anticancer activities of natural products and their analogues
3. Binding of small-molecule ligands to proteins
Projects:
1． Study on the synergistic antitumor effects of curcumin and its analogues in combination with low intensity ultrasound and the structural activity relationship. Liaoning Province Education Administration, No. LJC201908
2. Design, synthesis and reversal effect evaluation of 1,3-diaryl-4-piperidone analogues on multidrug resistance of cancer cells, No. LDQ201210(finished)
Papers:
1．Bingmi Liu, Zhongqiu Guo, Haotian Wu, Chuang Zhang, Li Li, Yu Liu*. A New Anti-Cancer Drug Delivery System: Polymeric Ionic Liquid Functionalized Reduced Graphene Oxide. Latin American Journal of Pharmacy, 38(2019): 1831-1837.
2．Liu, Y., Li, Q. Y., Wang, Y. P., Liu, Y. M., Liu, B., Liu, M. M., & Liu, B. M*. (2017). Spectroscopic investigation of the anticancer alkaloid piperlongumine binding to human serum albumin from the viewpoint of drug delivery. Luminescence. 33(2018): 305-311.
3．Bing-Mi Liu*, Jun Zhang, Ai-Jun Hao, Liang Xu, Dan Wang, Hui Ji, Shi-Jie Sun, Bo-Qi Chen, Bin Liu*. The increased binding affinity of curcumin with human serum albumin in the presence of rutin and baicalin: a potential for drug delivery system. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 155 (2016) 88–94.
4．Bing-Mi Liu, Jun Zhang, Xin Wang*, Li-Ping Zhang, Yang Liu, Hua-Ying Niu , Bin Liu*. Synthesis, DNA interaction and antimicrobial activities of three rimantadine analogues. Journal of Luminescence, 159 (2015) 128–133.
5．Bing-Mi Liu*, Chong-Liang Bai, JunZhang, YangLiu, Bo-YangDong, Yi-TongZhang, Bin Liu*. In vitro study on the interaction of 4,4-dimethylcurcumin with calfthymus DNA. Journal of Luminescence, 166 (2015) 48–53.
6．Bing-Mi Liu*, Jun Zhang, Chong-Liang Bai, Xin Wang, Xin-Zhi Qiu, Xiao-Li Wang, Hui Ji, Bin Liu*. Spectroscopic study on flavonoid-drug interactions: competitive binding for human serum albumin between three flavonoid compounds and ticagrelor, a new antiplatelet drug. Journal of Luminescence, 168 (2015) 69–76.
7．Bing-Mi Liu, Jun Zhang, Yang Liu, Li-Ping Zhang, Ping Ma, Xin Wang * and Bin Liu*. Multi-spectroscopic methods investigation on the interaction of tenoxicam with DNA. Luminescence, 30 (2015) 1313–1317.
8．LIU Bing-mi*, ZHANG Mei-hui, TAO Shu-juan, XIA Ming-yu, DONG Jin-hua*. Synthesis and antiproliferative effect of Mannich bases of demethoxycurcumin derivatives. Chinese Journal of Medicinal Chemistry, 24 (2014) 271–278.
9．Bing-Mi Liu, Ping Ma, Xin Wang, Yu-Mei Kong, Li-Ping Zhang, Bin Liu*. Synthesis of Three Rimantadine Schiff Bases and Their Biological Effects on Serum Albumin. Iranian Journal of Pharmaceutical Research, 13 (2014) 1183–1190.
10．Bing-Mi Liu, Ping Ma, Xin Wang, Yu-Mei Kong, Li-Ping Zhang and Bin Liu*. Spectroscopic Investigation on Protein Lesion by Tenoxicam under Ultrasound and Visible-Light Irradiation. Latin American Journal of Pharmacy, 33 (2014) 1492-1496.
11．Liu BM, Xia MY, Ji XL, Xu LY, Dong JH*. Synthesis and antiproliferative effect of novel curcumin analogues. Chemical and Pharmaceutical Bulletin, 61 (2013) 757–763.
12．Liu B*, Wang DJ, Liu BM, Wang L, He LL, Wang J, Xu SK. The influence of ultrasound on the fluoroquinolones antibacterial activity. Ultrasonics Sonochemistry, 18 (2011) 1052–1056.
13．Liu B, Wang DJ, Wang X, Liu BM, Kong YM, Wang D, Xu SK*. Spectroscopic investigation on protein damage by ciprofloxacin under ultrasonic irradiation. Spectrochimica Acta Part A, 78 (2011) 712–717.
14．Bin Liu, Jun Wang, Xin Wang, Bingmi Liu, Lingling He, Shukun Xu*. Synthesis and characterization of polymer eight-coordinate (enH2)[YIII(pdta) (H2O)]2·10H2O as well as the interaction of [YIII(pdta)(H2O)]22- with BSA. Spectrochim Acta A, 77 (2010) 1115–1121.
15．Liu B*, Wang J, Wang X, Liu BM, Kong YM, Wang D, Xu SK*. Spectrometric studies on the sonodynamic damage of protein in the presence of levofloxacin. Journal of Fluorescence, 20 (2010):985–992.
16．Ling-Ling He, Xin Wang*, Xiao-Xia Wu, Yong-Xia Wang, Yu-Mei Kong, Xin Wang, Bing-Mi Liu, Bin Liu. Protein damage and reactive oxygen species generation induced by the synergistic effects of ultrasound and methylene blue. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 134 (2015) 361–366.
Patents:
1. Curcumin analogues, their medicinal salts and preparations and applications. License number: ZL201210502684.6.
2. Four hydrogen curcumin analogues and their preparations and uses. License number: ZL 201310126499.6.
Contacts:
School of Pharmaceutical Sciences, Liaoning University,
No.66 Chongshan Mid-Road, Huanggu District, Shenyang, Liaoning, China 110036
Tel: 024-62202469
Fax: 024-62202469
Email: Liubingmi@163.com
