Wang Dan, senior experimentalist, master tutor, member of the Communist Party of China, is the director of undergraduate experimental center of the School of Pharmaceutical Science. She was honored as "Advanced Individual of Women Construction of Liaoning University", "Experimental teaching and Management Excellence Award" of Liaoning University, and won the third prize of Liaoning Natural Science Achievement Award. She has successively presided over the scientific plan projects of Liaoning Provincial Department of science and technology, the Project of Education Department of Liaoning Province, the scientific plan project of Shenyang Municipal Bureau of science and technology, the youth fund projects of Liaoning University and several horizontal scientific research projects. She also participated in 5 National Natural Science Foundation Projects, the fund projects of Liaoning Provincial Department of education and a number of educational reform projects as the main participant. To date, more than 20 scientific papers are published.

Academic backgroud:

Bachelor's Degree, Liaoning University, 1999-2003

Master’s Degree,  Liaoning University, 2004-2007

Doctor of Medicine(MD),  China Medical University, 2009-2014

Career highlights:

Senior experimentalist, School of Pharmaceutical Science, Liaoning University (2007– )

 Research highlights:

1.  Study on the molecular mechanism of antitumor drugs

2.  Study on the molecular mechanism of antidiabetic drugs

3. Study on the molecular mechanism of anti-inflammatory drugs

Projects:

1.     Study of the molecular mechanism of PPARγ  agonist Pseudolaric acids in alleviating insulin resistance in type 2 diabetes mellitus 2.   Project of Science and Technology Department of Liaoning Province, 20180551180.

2.     Study on the mechanism of inhibition of proliferation and metastasis of human endometrial carcinoma Ishikawa cells by Pseudolaric acid B. Project of Education Department of Liaoning Province,  L2015201.

3.     Study on the pathway of apoptosis and anti-metastasis of human gastric cancer cells MKN-45 induced by Pseudolaric acid B. Scientific plan project of Shenyang Municipal Bureau of science and technology, F13-316-1-63.

Papers:

1.     Wang D*, Xin Y, Tian Y, Li W, Sun D, Yang Y. Pseudolaric acid B inhibits gastric cancer cell metastasis in vitro and in haematogenous dissemination model through PI3K/AKT, ERK1/2 and mitochondria-mediated apoptosis pathways. Exp Cell Res. 2017 Mar 1;352(1):34-44.

2.     Wang D, Tian YQ，Feng WH, Zhao L, Zhao MY, Liu J, Wang QY. Pseudolaric acid B induces endometrial cancer Ishikawa cell apoptosis and inhibits metastasis through AKT-GSK-3β and ERK1/2 signaling pathways，Anti-cancer drugs, 2017, 28(6): 603-611.

3.     Ju Liu, Duanzheng Song, Yanqiu Tian, Xinwei Zhang, Yuefei Bai, Dan Wang*. Synthesis, crystal structure, and biological activity of 5- (4-fluorophenyl)- N,N- dimethyl-7- (trifluoromethyl) pyrazolo [1,5-a] pyrimidine-3-carboxamide[J]. J. Chem. Res., 2016, 40: 107-109.

4.     Ju Liu, Xue-Chen Hao, Ye Chen, Shi Ding, Hong-Sheng Liu, Dan Wang* . Synthesis of new substituted 5-amino-8H-phthalazino[1,2-b]quinazolin-8-one derivatives, J. Chem. Res. 2016, 41: 18-20.

5.     Xuelian Meng, Liangchao Zheng, Jia Liu, Chengcheng Gao, Machao Qiu, Yingying Liu, Jing Lv, Dan Wang, Changlan Chen*. Inhibitory effects of three bisbenzylisoquinoline alkaloids on lipopolysaccharide-induced microglial activation[J]. RSC Advances, 2017, 7, 18347–18357.

6.     Xuelian Meng, Changlan Chen*, Yingying Liu, Shujie Su, Jiangmin Gou, Fengning Huan, Dan Wang, Hongsheng Liu, Songbin Ben, Jing Lv*. Selenoprotein SELENOK Enhances the Migration and Phagocytosis of Microglial Cells by Increasing the Cytosolic Free Ca2+ Level Resulted from the Up-Regulation of IP3R[J]. Neuroscience, 2019, 38-49.

Contacts:

School of Pharmaceutical Science, Liaoning University,

No.66 Chongshan Middle Road, Huanggu District, Shenyang 110036, Liaoning, China

Tel: 024-62202469

Fax: 024-62202469

Email: wangdan@lnu.edu.cn